New Real-World Study Confirms High Efficacy of Continuous Diffusion of Oxygen (CDO) Therapy Across a Broad Range of Wounds – News By Wire

SAN ANTONIO, TX – December 17, 2025
EO2 Concepts (EO2), a leading developer in advanced wound care technology, is pleased to announce the publication of a new large-scale clinical analysis in the journal Oxygen (https://doi.org/10.3390/oxygen5040026).  This study demonstrates that Continuous Diffusion of Oxygen (CDO) therapy delivers strong and consistent results in real-world clinical settings, matching or exceeding outcomes seen in controlled clinical studies. The findings underscore CDO’s versatility and effectiveness for patients with complex wounds across varying types and anatomical locations.
Researchers analyzed data from a Prospective Patient Database (PPD) representing 764 patients receiving CDO therapy in diverse clinical practices. The study evaluated wound healing rates across multiple wound types, patient demographics, and age groups — including older patients in the Medicare population — and compared these real-world outcomes to results from controlled studies of CDO and Negative Pressure Wound Therapy (NPWT).
Using robust statistical methods — including the Kaplan–Meier and Cox proportional hazards models — the analysis revealed that CDO therapy achieved an average healing success rate of 76.3%, with rates ranging from 71.2% to 84.1% depending on wound type. Among Medicare-age patients (average age 78), healing outcomes were comparable to those of the overall population, and even slightly improved for pressure ulcers.
“Our analysis provides strong evidence that CDO therapy delivers consistently high healing rates across patient populations and wound types,” said Dr. Mark Q Niederauer, PhD, President & Chief Technology Officer. “These real-world findings reaffirm CDO’s clinical value, especially when compared to other advanced wound care modalities.”
When compared to NPWT, CDO therapy demonstrated markedly superior outcomes. Kaplan–Meier analysis showed that CDO achieved 79.2% full wound closure within 112 days, compared to 43.2% for NPWT in diabetic foot ulcers of similar size and severity.
The study concluded that CDO therapy’s clinical efficacy extends well beyond the controlled conditions of trials — performing reliably across everyday clinical practice environments.
Continuous Diffusion of Oxygen (CDO) Therapy
CDO therapy delivers continuous, low-flow oxygen directly to the wound site, supporting tissue regeneration and accelerating healing through improved oxygenation. It has been increasingly adopted as a non-invasive, patient-friendly alternative to traditional wound care methods.
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